2020年更新：
Ovalbumin 简称OVA，卵清蛋白（鸡）。因此，当OVA注射给小鼠会引发免疫反应。
OT-1小鼠是体内CD8+T特异性识别OVA
OT-11小鼠是体内CD4+T特异性识别OVA
这样有什么用呢，举个例子，表达OVA的肿瘤打给小鼠，再给小鼠OT-1的CD8+T,相当于给小鼠肿瘤特异性T细胞。（给个赞再走啊~谢谢！）
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OT-II: (CD4+---------ovalbumin 323-339 )
These transgenic mice express the mouse alpha-chain and beta-chain T cell receptor that pairs with the CD4 coreceptor and is specific for chicken ovalbumin 323-339 in the context of I-A b. Homozygous mice are viable and fertile. In these mice there is a four-fold increase in the CD4 to CD8 peripheral T cell ratio, and lymph node T cells demonstrate a dose-dependent proliferative response to the specific ovalbumin ligand. These transgenic mice are useful for studying in vivo T cell biology such as TCR-ligand interactions, T cell activation, thymic selection, cross-presentation of antigens, process of thymic selection and central and peripheral T cell tolerance and induction.
OT-I: (CD8+---------ovalbumin 257-264 )
These mice contain transgenic inserts for mouse Tcra-V2 and Tcrb-V5 genes. The transgenic T cell receptor was designed to recognize ovalbumin residues 257-264 in the context of pKb and used to study the role of peptides in positive selection and the response of CD8+ T cells to antigen. Like most TCR transgenics, these mice are somewhat immunodeficient.
