2020年更新：
Ovalbumin 簡稱OVA，卵清蛋白（雞）。因此，當OVA註射給小鼠會引發免疫反應。
OT-1小鼠是體內CD8+T特異性辨識OVA
OT-11小鼠是體內CD4+T特異性辨識OVA
這樣有什麽用呢，舉個例子，表達OVA的腫瘤打給小鼠，再給小鼠OT-1的CD8+T,相當於給小鼠腫瘤特異性T細胞。（給個贊再走啊~謝謝！）
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OT-II: (CD4+---------ovalbumin 323-339 )
These transgenic mice express the mouse alpha-chain and beta-chain T cell receptor that pairs with the CD4 coreceptor and is specific for chicken ovalbumin 323-339 in the context of I-A b. Homozygous mice are viable and fertile. In these mice there is a four-fold increase in the CD4 to CD8 peripheral T cell ratio, and lymph node T cells demonstrate a dose-dependent proliferative response to the specific ovalbumin ligand. These transgenic mice are useful for studying in vivo T cell biology such as TCR-ligand interactions, T cell activation, thymic selection, cross-presentation of antigens, process of thymic selection and central and peripheral T cell tolerance and induction.
OT-I: (CD8+---------ovalbumin 257-264 )
These mice contain transgenic inserts for mouse Tcra-V2 and Tcrb-V5 genes. The transgenic T cell receptor was designed to recognize ovalbumin residues 257-264 in the context of pKb and used to study the role of peptides in positive selection and the response of CD8+ T cells to antigen. Like most TCR transgenics, these mice are somewhat immunodeficient.
